Stimulation of subthalamic fibre tracts reduces dyskinesias in STN-DBS

Mov Disord. 2007 Apr 15;22(5):679-84. doi: 10.1002/mds.21387.


Rarely, the postoperative management of patients with subthalamic deep brain stimulation (STN-DBS) is complicated by pharmacologically intractable dyskinesias. Here we report that in three of these patients additional stimulation of a proximal contact located within the subthalamic white matter may lead to a significant reduction of dyskinesias associated with STN-DBS. We propose that pallidofugal fiber tracts play a major role in the etiopathology of dyskinesias and their blockade through DBS may explain our observations.

Publication types

  • Case Reports

MeSH terms

  • Deep Brain Stimulation / methods*
  • Dyskinesias / physiopathology
  • Dyskinesias / therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nerve Fibers / physiology*
  • Neurologic Examination
  • Parkinson Disease / physiopathology
  • Parkinson Disease / rehabilitation*
  • Postoperative Care / methods
  • Postoperative Complications / physiopathology
  • Postoperative Complications / therapy*
  • Subthalamic Nucleus / physiopathology*