Melatonin Effects on the Hypothalamo-Pituitary Axis in Fish

Trends Endocrinol Metab. 2007 Mar;18(2):81-8. doi: 10.1016/j.tem.2007.01.002. Epub 2007 Jan 30.


Melatonin, a hormonal output signal of vertebrate circadian clocks, contributes to synchronizing behaviors and neuroendocrine regulations with the daily and annual variations of the photoperiod. Conservation and diversity characterize the melatonin system: conservation because its pattern of production and synchronizing properties are a constant among vertebrates; and diversity because regulation of both its synthesis and modes of action have been profoundly modified during vertebrate evolution. Studies of the targets and modes of action of melatonin in fish, and their parallels in mammals, are of interest to our understanding of time-related neuroendocrine regulation and its evolution from fish to mammals, as well as for aquacultural purposes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Fishes / genetics
  • Fishes / growth & development
  • Fishes / physiology*
  • Hypothalamo-Hypophyseal System / drug effects*
  • Hypothalamo-Hypophyseal System / physiology
  • Melatonin / pharmacology*
  • Models, Biological
  • Pineal Gland / physiology
  • Pituitary-Adrenal System / drug effects*
  • Pituitary-Adrenal System / physiology
  • Receptors, Melatonin / genetics
  • Receptors, Melatonin / physiology
  • Reproduction / physiology


  • Receptors, Melatonin
  • Melatonin