Hyperthermic tumour-cell devitalization in vivo

Acta Radiol Ther Phys Biol. 1977 May;16(1):1-16. doi: 10.3109/02841867709133928.


A review of the morphologic, biochemical and clinical effects of hyperthermia on malignant cells indicates the presence of two principally different heat-induced alterations. (1) A 'destructive' lysosomal dependent cytoplasmic reaction dominates the tumour-cell devitalization in vivo, probably influenced by the characteristic tumour cell environment. (2) 'Repressive' nuclear abnormalities may be observed, but seem to be secondary in the in vivo reaction. However, under certain conditions (combined treatment modalities) this nuclear effect may be of importance.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleolus
  • Cells, Cultured
  • Cytoplasm / ultrastructure
  • Female
  • Hot Temperature / therapeutic use*
  • Humans
  • Hydrogen-Ion Concentration
  • Lysosomes
  • Mice
  • Mitosis
  • Neoplasms / therapy*
  • Neoplasms, Experimental / therapy
  • Neoplasms, Experimental / ultrastructure
  • RNA, Neoplasm / biosynthesis
  • Temperature


  • RNA, Neoplasm