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. 2007 Feb;30(2):363-6.
doi: 10.1248/bpb.30.363.

Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats

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Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats

Shin Tokunaga et al. Biol Pharm Bull. .
Free article

Abstract

In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (gamma-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.

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