New constituents from the leaves of Morinda citrifolia

Chem Pharm Bull (Tokyo). 2007 Feb;55(2):343-5. doi: 10.1248/cpb.55.343.

Abstract

A new iridoid glycoside, citrifoside (1), and a new anthraquinone, 1,5,15-trimethylmorindol (2), together with 24 known compounds, were isolated from the leaves of Morinda citrifolia. The structures of the new compounds were elucidated by spectral data. 1,5,15-Trimethylmorindol (2) did not show significant cytotoxic activity by itself but showed cytotoxicity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), while citrifoside (1) did not show any activity even with TRAIL.

MeSH terms

  • Anthraquinones / chemistry*
  • Anthraquinones / isolation & purification
  • Anthraquinones / pharmacology
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Humans
  • Iridoids / chemistry*
  • Iridoids / isolation & purification
  • Iridoids / pharmacology
  • Jurkat Cells / drug effects
  • Jurkat Cells / metabolism
  • Molecular Structure
  • Morinda / chemistry*
  • Plant Leaves / chemistry*
  • Plants, Medicinal*
  • TNF-Related Apoptosis-Inducing Ligand / metabolism

Substances

  • 1,5,15-trimethylmorindol
  • Anthraquinones
  • Glycosides
  • Iridoids
  • TNF-Related Apoptosis-Inducing Ligand
  • citrifoside