Chemical synthesis of branched RNAs: a new method for construction of synthetic units for branched RNAs by use of 2'-phosphorylation on the basis of steric control

M Sekine; S Iimura; T Mori; H Tsuruoka; K Furusawa

Chemical synthesis of branched RNAs: a new method for construction of synthetic units for branched RNAs by use of 2'-phosphorylation on the basis of steric control

Nucleic Acids Symp Ser. 1991:(25):65-6.

Authors

M Sekine¹, S Iimura, T Mori, H Tsuruoka, K Furusawa

Affiliation

¹ Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.

PMID: 1726812

Abstract

A 3',5'-unprotected 2'-O-bis(tert-butoxy)-phosphinyl-6-N-benzoyladenosine derivative was prepared as a key intermediate for the synthesis of branched RNAs, and used for construction of building units from which chain elongation in any of 2'-, 3'-, and 5'-directions would be possible. From this synthetic intermediate, 2'-phosphorylated ApC dimer was also synthesized.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Molecular Sequence Data
Molecular Structure
Oligoribonucleotides / chemical synthesis
Oligoribonucleotides / chemistry
Phosphorylation
RNA / chemical synthesis*
RNA / chemistry

Substances

Oligoribonucleotides
RNA