Amelioration of aluminium-induced liver damage by vitamin E

Saudi Med J. 2007 Feb;28(2):197-200.


Objective: To investigate the effects of aluminium sulphate on the microscopic morphology of the liver and on vitamin E amelioration of aluminium-induced liver damage.

Methods: Rats were injected intraperitoneally with aluminium sulphate alone or aluminium sulphate together with vitamin E, with saline injected rats used as the control group. The study took place in Pamukkale University Faculty of Medicine in 2005.

Results: The rats exposed to aluminium showed morphological changes in addition to previously reported biochemical changes in the liver. The anti-oxidant vitamin E significantly diminished the liver damage seen due to aluminium.

Conclusion: There is an apparent protective effect of vitamin E on parenteral aluminium exposure.

MeSH terms

  • Alum Compounds / pharmacology
  • Alum Compounds / toxicity*
  • Animals
  • Biopsy, Needle
  • Chemical and Drug Induced Liver Injury
  • Dietary Supplements
  • Disease Models, Animal
  • Drug Interactions
  • Immunohistochemistry
  • Injections, Intraperitoneal
  • Liver / drug effects
  • Liver / pathology*
  • Liver Diseases / pathology
  • Liver Diseases / prevention & control*
  • Male
  • Oxidative Stress / drug effects
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Reference Values
  • Sensitivity and Specificity
  • Vitamin E / pharmacology*


  • Alum Compounds
  • Vitamin E
  • aluminum sulfate