A modeling paradigm incorporating parametric and non-parametric methods

D Song; Z Wang; V Z Marmarelis; T W Berger

doi:10.1109/IEMBS.2004.1403241

A modeling paradigm incorporating parametric and non-parametric methods

Conf Proc IEEE Eng Med Biol Soc. 2004:2006:647-50. doi: 10.1109/IEMBS.2004.1403241.

Authors

D Song¹, Z Wang, V Z Marmarelis, T W Berger

Affiliation

¹ Dept. of Biomedical Eng., Southern California Univ., Los Angeles, CA, USA.

PMID: 17271760
DOI: 10.1109/IEMBS.2004.1403241

Abstract

A novel parametric/non-parametric modeling paradigm was defined and used in characterization of synaptic transmission. In this paradigm, parametric and nonparametric techniques were incorporated in a complementary manner. Non-parametric method was used to generalize experimental data and extract system input/output properties. It provided a quantitative and intuitive way to validate a parametric model with respect to general, complete input patterns. Biological processes or mechanisms missed by the conventional parametric modeling approach were revealed and subsequently included into the modified parametric model.