Noninvasive infrared imaging for quantitative assessment of tumor vasculature and response to therapy

Moinuddin Hassan; David Hattery; Abby Vogel; Victor Chernomordik; Stavros Demos; Karen Aleman; Richard Little; Robert Yarchoan; Amir H Gandjbakhche

doi:10.1109/IEMBS.2004.1403383

Noninvasive infrared imaging for quantitative assessment of tumor vasculature and response to therapy

Conf Proc IEEE Eng Med Biol Soc. 2004:2004:1200-2. doi: 10.1109/IEMBS.2004.1403383.

Authors

Moinuddin Hassan¹, David Hattery, Abby Vogel, Victor Chernomordik, Stavros Demos, Karen Aleman, Richard Little, Robert Yarchoan, Amir H Gandjbakhche

Affiliation

¹ Lab. of Integrative & Med. Biophys., Nat. Inst. of Health, Bethesda, MD, USA.

PMID: 17271902
DOI: 10.1109/IEMBS.2004.1403383

Abstract

In this study we are investigating three infrared imaging techniques, thermography, multispectral imaging and Laser Doppler imaging (LDI) to assess parameters of vascularity in lesions of Kaposi's sarcoma (KS) and response to therapy. Thermography, multispectral imaging and LDI were recorded over the lesion and compare to normal skin either adjacent to the lesion or on the contralateral side. The KS lesions generally had increased temperature, blood volume (as measured by multispectral imaging) and blood flux (as measured by LDI) as compare to normal skin. After the treatment with experimental antiKS drug, temperature, blood volume and blood flow of the lesion were significantly reduced from the baseline. These techniques hold promise to assess physiological parameter in KS lesion and their changes with therapy.