The "all-or-none" law in skeletal muscle and nerve fibres

Arch Ital Biol. 2007 Jan;145(1):39-54.

Abstract

In 1905 the Cambridge physiologist Keith Lucas extended the "all-or-none" principle (introduced by H. P. Bowditch for the cardiac tissue) to skeletal muscle and nerve fibres. Nevertheless, in a short time it was clear that nerve fibres obey this law, but also that frequency of discharge is another relevant factor in the nervous conduction.

Publication types

  • Historical Article

MeSH terms

  • Animals
  • Germany
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Models, Animal
  • Motor Neurons / physiology*
  • Muscle Contraction / physiology
  • Muscle, Skeletal / innervation*
  • Muscle, Skeletal / physiology*
  • Neural Conduction / physiology
  • Neuromuscular Junction / physiology
  • Neurophysiology / history*
  • Peripheral Nerves / physiology*
  • United Kingdom