Vaccine delivery methods using viral vectors

Mol Pharm. Jan-Feb 2007;4(1):18-32. doi: 10.1021/mp060098+.

Abstract

Viral vectors have different capabilities as gene delivery vehicles for vaccines and immunotherapeutics. This review discusses selected viral vector systems and plasmid DNA and provides an overview of their specific characteristics, strengths, and limitations. The features, modes of viral entry and replication, expression of heterologous proteins, issues related to both preexisting and heterologous immunity, and vaccine strategies are discussed for the different vectors. Comparisons of the features and capabilities of the vectors are provided.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA, Viral / metabolism*
  • Drug Delivery Systems*
  • Genetic Vectors*
  • Humans
  • Vaccines, DNA / administration & dosage*
  • Vaccines, DNA / immunology*
  • Viruses

Substances

  • DNA, Viral
  • Vaccines, DNA