Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats

World J Gastroenterol. 2007 Jan 28;13(4):607-11. doi: 10.3748/wjg.v13.i4.607.


Aim: To examine the anti-ulcerogenic and antioxidant effects of aqueous extracts of Foeniculum vulgare (FVE) on ethanol-induced gastric lesions in rats.

Methods: FVE was administered by gavage at doses of 75, 150 and 300 mg/kg, and famotidine was used at the dose of 20 mg/kg. Following a 60 min period, all the rats were given 1 mL of ethanol (80%) by gavage. One hour after the administration of ethanol, all groups were sacrificed, and the gastric ulcer index was calculated; whole blood malondialdehyde (MDA) and reduced glutathione (GSH), serum nitrate, nitrite, ascorbic acid, retinol and beta-carotene levels were measured in all the groups.

Results: It was found that pretreatment with FVE significantly reduced ethanol-induced gastric damage. This effect of FVE was highest and statistically significant in 300 mg/kg group compared with the control (4.18 +/- 2.81 vs 13.15 +/- 4.08, P < 0.001). Also, pretreatment with FVE significantly reduced the MDA levels, while significantly increased GSH, nitrite, nitrate, ascorbic acid, retinol and beta-carotene levels.

Conclusion: FVE has clearly a protective effect against ethanol-induced gastric mucosal lesion, and this effect, at least in part, depends upon the reduction in lipid peroxidation and augmentation in the antioxidant activity.

MeSH terms

  • Animals
  • Antioxidants / therapeutic use
  • Ethanol / toxicity*
  • Foeniculum*
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / pathology
  • Glutathione / blood
  • Lipid Peroxidation
  • Malondialdehyde / blood
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Stomach Ulcer / prevention & control


  • Antioxidants
  • Plant Extracts
  • Ethanol
  • Malondialdehyde
  • Glutathione