Imaging of iris lesions with high-speed optical coherence tomography

Ophthalmic Surg Lasers Imaging. 2007 Jan-Feb;38(1):27-34. doi: 10.3928/15428877-20070101-04.


Background and objectives: To image and measure iris tumors with optical coherence tomography (OCT).

Patients and methods: High-speed (2,000-4,000 axial-scan/sec and 4-16 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma. OCT images were compared with slit-lamp photography and ultrasound biomicroscopy.

Results: OCT at 1.3-micron wavelength could penetrate the full thickness of the iris lesions and allow three-dimensional measurement of lesion size. Internal reflectivity is correlated with pigmentation. OCT is a convenient non-contact method that provides imaging of the clinically important angle structures (scleral spur and angle recess).

Conclusions: OCT is a new imaging modality that complements slit-lamp photography and ultrasound biomicroscopy for serial evaluation of iris

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Diagnosis, Differential
  • Female
  • Humans
  • Iris / diagnostic imaging
  • Iris / pathology*
  • Iris Neoplasms / diagnosis*
  • Male
  • Melanoma / diagnosis*
  • Microscopy, Acoustic
  • Middle Aged
  • Nevus / diagnosis*
  • Tomography, Optical Coherence / methods*