Prevention of recurrent bacterial urinary tract infections by intravesical instillation of hyaluronic acid

Int J Gynaecol Obstet. 2007 Mar;96(3):192-5. doi: 10.1016/j.ijgo.2006.11.025. Epub 2007 Feb 5.


Objective: To evaluate the efficacy of vesical instillation of hyaluronic acid against recurrent urinary tract infections.

Methods: Twenty women with a history of recurrent urinary tract infections each received 9 intravesical instillations of hyaluronic acid over 6 months. Their status was assessed prospectively over 47.6 weeks and compared with a retrospective review of patient charts covering 36.2+/-6.2 weeks.

Results: The total numbers of urinary tract infections were 67 before and 10 after treatment (p<0.001). Thirteen patients (65%) were free of recurrences until the end of the study. One had a recurrence during treatment, and 6 (30%) during follow-up. The number of infections per year per patient was reduced from 4.99+/-0.92 to 0.56+/-0.82 (p<0.001). In women with recurrences, time to recurrence was 178.3+/-25.5 days, compared with 76.7+/-24.6 days before treatment (p<0.001).

Conclusion: Intravesical instillation of hyaluronic acid is effective in preventing recurrent urinary tract infections.

Publication types

  • Clinical Trial

MeSH terms

  • Adjuvants, Immunologic / therapeutic use*
  • Administration, Intravesical
  • Adolescent
  • Adult
  • Female
  • Follow-Up Studies
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Prospective Studies
  • Retrospective Studies
  • Secondary Prevention
  • Time Factors
  • Urinary Tract Infections / prevention & control*


  • Adjuvants, Immunologic
  • Hyaluronic Acid