HLA-A29.2 subtype associated with birdshot retinochoroidopathy

Am J Ophthalmol. 1992 Jan 15;113(1):33-5. doi: 10.1016/s0002-9394(14)75749-6.


Birdshot retinochoroidopathy is strongly associated with HLA-A29. This antigen can be divided into two subtypes, A29.1 and A29.2, using an immunoprecipitation method succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58 subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the results showed that HLA-A29.2 subtype was present in all patients (100%). We concluded that the absence of HLA-A29.1 subtype is statistically significant (P less than .01) in this study of HLA-A29 subtyping.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Chorioretinitis / immunology*
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Genetic Linkage / immunology
  • HLA-A Antigens / analysis*
  • Histocompatibility Testing
  • Humans
  • Immunophenotyping
  • Male
  • Middle Aged
  • Risk Factors


  • HLA-A Antigens
  • HLA-A29 antigen