Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients

Am J Psychiatry. 1992 Jan;149(1):118-20. doi: 10.1176/ajp.149.1.118.


The authors measured intracellular Ca2+ concentrations in four manic and five bipolar depressed patients and seven comparison subjects. Platelet and lymphocyte intracellular Ca2+ concentrations were comparable. The patients' mean intracellular Ca2+ concentrations were higher than those of the comparison subjects and demonstrated more interindividual variation. These findings suggest a diffuse abnormality in mechanisms affecting intracellular calcium homeostasis in bipolar disorder.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Bipolar Disorder / blood*
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / physiopathology
  • Blood Platelets / chemistry*
  • Calcium / blood*
  • Calcium / physiology
  • Female
  • Humans
  • Intracellular Fluid / chemistry
  • Lymphocytes / chemistry*
  • Male
  • Middle Aged
  • Second Messenger Systems / physiology


  • Calcium