Relation between level or change of hemoglobin and generic and disease-specific quality of life measures in hemodialysis

Qual Life Res. 2007 Jun;16(5):755-65. doi: 10.1007/s11136-007-9176-6. Epub 2007 Feb 8.


Objective: We sought to examine the relation between meeting or exceeding the current minimum guideline for hemoglobin (11 g/dl) in dialysis patients and generic and disease-specific QOL scores at 1 year.

Methods: In 438 incident hemodialysis patients from a national prospective cohort study, we used regression models to predict QOL score (all scaled 0-100) at 1 year using 6-month values of hemoglobin, adjusting for potential confounders.

Results: Compared to values < 11 g/dl, hemoglobin > or = 11 g/dl at 6 months was associated with higher scores for the general domains of physical functioning, role physical, mental health, social functioning, and bodily pain at 1 year; cognitive function, diet restriction, and dialysis access dialysis-specific domain scores were also higher for these patients. Each 1 g/dl greater hemoglobin was also statistically significantly associated with higher QOL scores for most domains. In longitudinal analyses, most of the domains showed that, with each 1 g/dl increase in hemoglobin concentration from baseline to 6 months, QOL score increased significantly over the first year.

Conclusions: Hemodialysis patients who attain higher hemoglobin concentration at 6 months, especially > or = 11 g/dl, have better QOL at 1 year, with regard to important physical, mental, social, and cognitive domains.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia / prevention & control*
  • Anemia / psychology
  • Female
  • Hemoglobins / analysis*
  • Humans
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Prospective Studies
  • Psychological Tests
  • Quality of Life*
  • Renal Dialysis / psychology*
  • Sickness Impact Profile*
  • Surveys and Questionnaires
  • Time Factors
  • United States


  • Hemoglobins