Factors associated with health-related quality of life among hemodialysis patients in the DOPPS

Qual Life Res. 2007 May;16(4):545-57. doi: 10.1007/s11136-006-9143-7. Epub 2007 Feb 8.


Objective: To identify modifiable factors associated with health-related quality of life (HRQOL) among chronic hemodialysis patients.

Methods: Analysis of baseline data of 9,526 hemodialysis patients from seven countries enrolled in phase I of the Dialysis Outcomes and Practice Patterns Study (DOPPS). Using the Kidney Disease Quality of Life Short Form (KDQOL-SF(TM)), we determined scores for 8 generic scale summaries derived from these scales, i.e., the physical component summary [PCS] and mental component summary [MCS], and 11 kidney disease- targeted scales. Regression models were used to adjust for differences in comorbidities and sociodemographic and treatment factors. The Benjamini-Hochberg procedure was used to correct P-values for multiple comparisons.

Results: Unemployment and psychiatric disease were independently and significantly associated with lower scores for all generic and several kidney disease-targeted HRQOL measures. Several other comorbidities, lower educational level, lower income, and hypoalbuminemia were also independently and significantly associated with lower scores of PCS and/or MCS and several generic and kidney disease-targeted scales. Hemodialysis by catheter was associated with significantly lower PCS scores, partially explained by the correlation with covariates.

Conclusion: Associations of poorer HRQOL with preventable or controllable factors support a greater focus on psychosocial and medical interventions to improve the well-being of hemodialysis patients.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Comorbidity
  • Europe
  • Female
  • Humans
  • Internationality
  • Japan
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / psychology
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Quality of Life*
  • Renal Dialysis / psychology*
  • Sickness Impact Profile*
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • United States