The raphe magnus/pallidus regulates sweat secretion and skin vasodilation of the cat forepaw pad: a preliminary electrical stimulation study

Neurosci Lett. 2007 Mar 30;415(3):283-7. doi: 10.1016/j.neulet.2007.01.033. Epub 2007 Jan 19.

Abstract

In the human palm/sole, mental or physical stimuli induce an increase in sweat secretion and a decrease in skin blood flow (SkBF). However, the central pathways of these responses remain unclear. We measured sweat secretion and SkBF in the cat footpad by electrically stimulating the raphe. Stimulation of the rostral raphe magnus/pallidus elicited a reduction in SkBF without affecting sweat secretion. Stimulation of the mid to caudal raphe magnus/pallidus elicited an increase in both sweat secretion and SkBF. The raphe magnus/pallidus may play a crucial role in skin vasomotor and sudomotor responses in the cat footpad.

MeSH terms

  • Animals
  • Autonomic Pathways / physiology
  • Body Temperature Regulation / physiology
  • Cats
  • Efferent Pathways / physiology
  • Electric Stimulation
  • Forelimb / blood supply
  • Forelimb / innervation*
  • Male
  • Medulla Oblongata / anatomy & histology
  • Medulla Oblongata / physiology
  • Microcirculation / innervation*
  • Microcirculation / physiology
  • Raphe Nuclei / anatomy & histology
  • Raphe Nuclei / physiology*
  • Regional Blood Flow / physiology
  • Skin / blood supply
  • Skin / innervation*
  • Sweat Glands / innervation*
  • Sweat Glands / metabolism
  • Sweating / physiology
  • Vasodilation / physiology*
  • Vasomotor System / physiology