Translocation (8;21) in two cases of refractory anemia with excess of blasts in transformation

E Maserati; M Casali; F Pasquali; F Locatelli; S Giani; L Prete; M Zecca; R Invernizzi; R Bassan

doi:10.1016/0165-4608(92)90138-x

Translocation (8;21) in two cases of refractory anemia with excess of blasts in transformation

Cancer Genet Cytogenet. 1992 Jan;58(1):76-8. doi: 10.1016/0165-4608(92)90138-x.

Authors

E Maserati¹, M Casali, F Pasquali, F Locatelli, S Giani, L Prete, M Zecca, R Invernizzi, R Bassan

Affiliation

¹ Biologia Generale e Genetica Medica, Università di Pavia, Italy.

PMID: 1728955
DOI: 10.1016/0165-4608(92)90138-x

Abstract

We report two cases of refractory anemia with excess of blasts in transformation (RAEB-T) with the translocation (8;21), which is frequent in ANLL but not in myelodysplastic syndromes (MDS). A review of such cases leads us to conclude that myeloproliferative disorders characterized by the t(8;21) may be preceded by an MDS phase.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Review

MeSH terms

Anemia, Refractory, with Excess of Blasts / genetics*
Anemia, Refractory, with Excess of Blasts / pathology
Blast Crisis*
Child, Preschool
Chromosomes, Human, Pair 21*
Chromosomes, Human, Pair 8*
Female
Humans
Male
Middle Aged
Translocation, Genetic*