Chemical genetics: where genetics and pharmacology meet

Cell. 2007 Feb 9;128(3):425-30. doi: 10.1016/j.cell.2007.01.021.

Abstract

Genetics and pharmacology can elicit surprisingly different phenotypes despite targeting the same protein. This Essay explores these unexpected differences and their implications for biology and medicine.

MeSH terms

  • Allosteric Regulation
  • Animals
  • Enzyme Inhibitors / pharmacology*
  • Genetic Techniques
  • Mutation
  • Phenotype
  • Phosphotransferases / antagonists & inhibitors
  • Phosphotransferases / drug effects*
  • Phosphotransferases / genetics*
  • Phosphotransferases / metabolism
  • Proteins / drug effects
  • Proteins / genetics
  • Proteins / metabolism

Substances

  • Enzyme Inhibitors
  • Proteins
  • Phosphotransferases