Ph-positive chronic myeloid leukemia with t(8;21)(q22;q22) in blastic crisis

Cancer Genet Cytogenet. 1992 Jan;58(1):96-9. doi: 10.1016/0165-4608(92)90143-v.


A patient diagnosed with chronic myeloid leukemia was studied periodically during his illness. The result showed the presence of a Philadelphia (Ph) chromosome by a 9;22 translocation as a single abnormality to the time of blastic crisis. At that time, the chromosome studies showed a clonal evolution. Furthermore, a second derivated line was added to the Ph line. This new anomaly consisted of a 8;21 translocation, considered as specific of M2 type acute nonlymphoblastic leukemia of French-American-British classification.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blast Crisis*
  • Chromosomes, Human, Pair 21*
  • Chromosomes, Human, Pair 8*
  • Humans
  • Karyotyping
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • Male
  • Philadelphia Chromosome*
  • Translocation, Genetic*