Intracellular pH sensors: design principles and functional significance

Physiology (Bethesda). 2007 Feb;22:30-9. doi: 10.1152/physiol.00035.2006.


Changes in intracellular pH regulate many cell behaviors, including proliferation, migration, and transformation. However, our understanding of how physiological changes in pH affect protein conformations and macromolecular assemblies is limited. We present design principles, current modeling predictions, and examples of pH sensors or proteins that have activities or ligand-binding affinities that are regulated by changes in intracellular pH.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acid-Base Equilibrium / physiology
  • Animals
  • Cytoskeletal Proteins / chemistry*
  • Cytoskeletal Proteins / physiology*
  • Humans
  • Hydrogen-Ion Concentration*
  • Protein Conformation
  • Receptors, Cell Surface / chemistry*
  • Receptors, Cell Surface / physiology*
  • Signal Transduction / physiology
  • Structure-Activity Relationship


  • Cytoskeletal Proteins
  • Receptors, Cell Surface