Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets

Physiology (Bethesda). 2007 Feb;22:56-64. doi: 10.1152/physiol.00033.2006.


Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy
  • Cardiomegaly / pathology
  • Cardiomegaly / physiopathology*
  • Cardiomegaly / therapy*
  • Heart Failure / pathology
  • Heart Failure / physiopathology*
  • Heart Failure / therapy*
  • Humans
  • Myocytes, Cardiac / pathology
  • Myocytes, Cardiac / physiology
  • Necrosis