Essential tremor: phenotypic expression in a clinical cohort

Parkinsonism Relat Disord. 2007 Aug;13(6):333-9. doi: 10.1016/j.parkreldis.2006.12.004. Epub 2007 Feb 8.


Objectives: Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria.

Methods: A clinical series of 487 consecutive individuals diagnosed with ET were included for study.

Results: The sample was 53% male, had a mean age of onset of 52, and a mean age of 71. Half of the sample had a family history of ET. Half presented with asymmetrical disease and tremor affected the arms (97%), voice (62%), and head or neck (48%). There was considerable variability in the base rate of individuals fulfilling various commonly used diagnostic criteria of ET.

Conclusion: The sample was deemed representative of ET clinical cohorts. Asymmetric disease was common, and there was considerable base-rate variation across traditional ET diagnostic criteria.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Aged
  • Cohort Studies
  • Demography
  • Disease Progression
  • Essential Tremor / diagnosis*
  • Essential Tremor / physiopathology*
  • Female
  • Humans
  • Male
  • Phenotype*