Elevated C-reactive protein in acute coronary syndrome presentation is an independent predictor of long-term mortality and heart failure

Clin Biochem. 2007 Mar;40(5-6):326-9. doi: 10.1016/j.clinbiochem.2006.10.025. Epub 2007 Jan 5.


Objectives: To assess the ability of C-reactive protein (CRP) to predict long-term outcomes in a chest pain population.

Design and methods: CRP was measured at presentation in 446 emergency department patients with acute coronary syndromes. All-cause mortality and hospital discharges for acute myocardial infarction (AMI) and congestive heart failure (CHF) were obtained for up to 8 years following the event.

Results: Kaplan-Meier analyses indicated that patients with CRP concentrations above the American Heart Association scientific statement cut-off had a higher rate for death and CHF admissions. After adjusting for troponin concentrations, in a Cox proportional hazard model, only CRP concentrations indicative of an acute phase response (i.e., >7.44 mg/L) were associated with a significant risk for death after 5 years and CHF readmission after 2 years.

Conclusions: Patients presenting early with chest pain with elevated CRP concentrations have a greater long-term risk for death and heart failure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood*
  • C-Reactive Protein / metabolism*
  • Female
  • Heart Failure / blood*
  • Heart Failure / metabolism
  • Heart Failure / mortality
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Myocardial Infarction / blood*
  • Myocardial Infarction / metabolism
  • Myocardial Infarction / mortality
  • Proportional Hazards Models
  • Survival Rate


  • Biomarkers
  • C-Reactive Protein