Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?

Curr Opin Immunol. 2007 Apr;19(2):203-8. doi: 10.1016/j.coi.2007.02.001. Epub 2007 Feb 9.


When immune cells and developing tumor cells localize to a common microenvironment, an assemblage of interactions takes place; this results in either tumor destruction by way of immunosurveillance or tumor outgrowth. These events put a functional imprint onto the emerging tumor repertoire because tumor cells arising in the presence of a fully functional immune system are less immunogenic than those that develop in the absence of immunity (i.e. in RAG2(-/-) and perforin(-/-) mice). However, other studies suggest that the immune system can also actively promote formation of certain tumors. These apparent disparate effects of immunity on tumorigenesis provide a unique model for study of the decision-making process that dictates immune function within a tumor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • Disease Models, Animal
  • Immunity / genetics
  • Immunologic Surveillance*
  • Inflammation / immunology*
  • Interferons / metabolism
  • Interleukin-23 / metabolism
  • Membrane Glycoproteins / genetics
  • Mice
  • Neoplasms / immunology*
  • Perforin
  • Pore Forming Cytotoxic Proteins / genetics
  • Receptors, Immunologic / metabolism
  • Receptors, Natural Killer Cell


  • DNA-Binding Proteins
  • Interleukin-23
  • Membrane Glycoproteins
  • Pore Forming Cytotoxic Proteins
  • Rag2 protein, mouse
  • Receptors, Immunologic
  • Receptors, Natural Killer Cell
  • Perforin
  • Interferons