A radical role for p38 MAPK in tumor initiation

Norman J Kennedy; Cristina Cellurale; Roger J Davis

doi:10.1016/j.ccr.2007.01.009

A radical role for p38 MAPK in tumor initiation

Cancer Cell. 2007 Feb;11(2):101-3. doi: 10.1016/j.ccr.2007.01.009.

Authors

Norman J Kennedy¹, Cristina Cellurale, Roger J Davis

Affiliation

¹ Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

PMID: 17292820
DOI: 10.1016/j.ccr.2007.01.009

Abstract

It is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Cancer Cell shows that p38 MAP kinase plays a selective role in tumor initiation mediated by oxidative stress.

Publication types

Comment

MeSH terms

Animals
Apoptosis
Cell Transformation, Neoplastic*
Humans
Mitogen-Activated Protein Kinase 14 / genetics
Mitogen-Activated Protein Kinase 14 / physiology*
Neoplasms / enzymology*
Neoplasms / pathology
Oxidative Stress*
Reactive Oxygen Species / metabolism
Signal Transduction

Substances

Reactive Oxygen Species
Mitogen-Activated Protein Kinase 14