Angiotensin-(1-7) and the renin-angiotensin system

Curr Opin Nephrol Hypertens. 2007 Mar;16(2):122-8. doi: 10.1097/MNH.0b013e328031f362.

Abstract

Purpose of review: In this review we will focus on the recent findings related to angiotensin-(1-7) as an angiotensin II counter-regulatory peptide within the renin-angiotensin system.

Recent findings: The identification of the angiotensin-converting enzyme homologue ACE2 as an angiotensin peptide processing enzyme and of Mas as a receptor for angiotensin-(1-7) has contributed to establishing this heptapeptide as a biologically active member of the renin-angiotensin system cascade.

Summary: The previously unsuspected complexity of the renin-angiotensin system, unmasked by novel findings, has revealed new possibilities for exploring its physiological and pathophysiological roles. In addition, the ACE2-angiotensin-(1-7)-Mas axis may be seriously considered as a putative target for the development of new cardiovascular drugs.

Publication types

  • Review

MeSH terms

  • Angiotensin I / physiology*
  • Endothelium, Vascular / physiology*
  • Heart / physiology*
  • Humans
  • Kidney / physiology*
  • Peptide Fragments / physiology*
  • Proto-Oncogene Proteins / physiology
  • Receptors, G-Protein-Coupled / physiology
  • Renin-Angiotensin System / physiology*
  • Signal Transduction / physiology

Substances

  • Peptide Fragments
  • Proto-Oncogene Proteins
  • Receptors, G-Protein-Coupled
  • proto-oncogene proteins c-mas-1
  • Angiotensin I
  • angiotensin I (1-7)