PET kinetic analysis--compartmental model

Ann Nucl Med. 2006 Nov;20(9):583-8. doi: 10.1007/BF02984655.


PET enables not only visualization of the distribution of radiotracer, but also has ability to quantify several biomedical functions. Compartmental model is a basic idea to analyze dynamic PET data. This review describes the principle of the compartmental model and categorizes the techniques and approaches for the compartmental model according to various aspects: model design, experimental design, invasiveness, and mathematical solution. We also discussed advanced applications of the compartmental analysis with PET.

Publication types

  • Review

MeSH terms

  • Computer Simulation
  • Data Interpretation, Statistical
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Humans
  • Kinetics
  • Magnetic Resonance Imaging
  • Models, Theoretical
  • Neoplasm Staging
  • Positron-Emission Tomography / instrumentation*
  • Positron-Emission Tomography / methods*
  • Radioisotopes / pharmacokinetics*
  • Telencephalon / pathology
  • Tomography, Emission-Computed, Single-Photon / methods


  • Radioisotopes
  • Fluorodeoxyglucose F18