Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions

Trends Cell Biol. 2007 Mar;17(3):145-56. doi: 10.1016/j.tcb.2007.01.003. Epub 2007 Feb 12.


Cellular adhesion, motility, endocytosis, exocytosis and cytokinesis involve the coordinated reorganization of the cytoskeleton and of the plasma membrane. The 'Pombe Cdc15 homology' (PCH) family of adaptor proteins has recently been shown to coordinate the membrane and cytoskeletal dynamics involved in these processes by curving membranes, recruiting dynamin and controlling the architecture of the actin cytoskeleton. Mutations in PCH family members or proteins that interact with them are associated with autoinflammatory, neurological or neoplastic diseases. Here, we review the nature, actions and disease associations of the vertebrate PCH family members, highlighting their fundamental roles in the regulation of processes involving membrane-cytoskeletal interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Actins / metabolism
  • Adaptor Proteins, Signal Transducing / chemistry
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Membrane / metabolism*
  • Cytoskeleton / metabolism*
  • Humans
  • Protein Binding
  • Protein Transport


  • Actins
  • Adaptor Proteins, Signal Transducing