Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma

Haematologica. 2007 Feb;92(2):264-6. doi: 10.3324/haematol.10356.


We explored the role of interleukin-7 (IL-7) in the bone marrow (BM) stroma-mediated survival of primary T-cell acute lymphoblastic leukemia (T-ALL) cells and normal thymocytes. We presented evidence that IL-7 has a major role in the enhanced survival mediated by BM stroma both in T-ALL cells and thymocytes.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Cells / cytology*
  • Cell Proliferation
  • Cell Survival
  • Child
  • Child, Preschool
  • Coculture Techniques
  • Flow Cytometry
  • Humans
  • Infant
  • Interleukin-7 / biosynthesis
  • Interleukin-7 / physiology*
  • Lymphopoiesis
  • Mice
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*
  • Thymus Gland / cytology*
  • Thymus Gland / metabolism


  • Interleukin-7