Auditory efferent activation in CBA mice exceeds that of C57s for varying levels of noise

J Acoust Soc Am. 2007 Jan;121(1):EL29-34. doi: 10.1121/1.2401226.

Abstract

The medial olivocochlear efferent (MOC) system enhances signals in noise and helps mediate auditory attention. Contralateral suppression (CS) of distortion product otoacoustic emissions (DPOAEs) has revealed age-related MOC declines. Here, differences in CS as a function of contralateral noise intensity (43-67 dB sound pressure level) were measured; 2f1-f2 DPOAE grams were recorded for young adult CBA and C57 mice. In CBAs, CS was a monotonic function of contralateral noise level. The C57s showed normal hearing, measured with DPOAE amplitudes and auditory brainstem response thresholds, but showed little CS, suggesting a loss of efferent dynamics preceding any deficiencies of the afferent auditory system.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Auditory Perception / physiology*
  • Feedback / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Neurons, Efferent / physiology*
  • Noise*
  • Species Specificity