Fleshing out filaggrin phenotypes

J Invest Dermatol. 2007 Mar;127(3):504-7. doi: 10.1038/sj.jid.5700695.


The association of filaggrin null alleles with eczema has been replicated in several European populations. Three large, well-conducted studies confirm this association and offer insights into the phenotypic nature of eczema associated with these alleles. Early data suggest that FLG-associated eczema may be more persistent, more likely to have palmar hyperlinearity, and more likely to be associated with asthma. These initial hints will require further confirmation in cohort studies.

Publication types

  • Comment

MeSH terms

  • Alleles
  • Asthma / genetics*
  • Eczema / diagnosis*
  • Eczema / genetics*
  • Genetic Predisposition to Disease
  • Humans
  • Intermediate Filament Proteins / genetics*
  • Intermediate Filament Proteins / physiology*
  • Models, Genetic
  • Phenotype
  • Research Design
  • Risk Factors


  • Intermediate Filament Proteins
  • filaggrin