In search of partners: linking extracellular proteases to substrates

Nat Rev Mol Cell Biol. 2007 Mar;8(3):245-57. doi: 10.1038/nrm2120. Epub 2007 Feb 14.


Proteases function as molecular switches in signalling circuits at the cell surface and in the extracellular milieu. In light of the many proteases that are encoded by the genome, and the even larger number of bioactive substrates, it is crucial to identify which proteases cleave a particular substrate and which substrates individual proteases cleave. Elucidating the substrate degradomes of proteases will help us to understand the function of proteases in development and disease and to validate proteases as drug targets.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Peptide Hydrolases / chemistry*
  • Peptide Hydrolases / genetics
  • Peptide Hydrolases / metabolism*
  • Proteomics / methods*
  • Substrate Specificity


  • Peptide Hydrolases