Transmission of Drug-Resistant Tuberculosis Among Treated Patients in Shanghai, China

J Infect Dis. 2007 Mar 15;195(6):864-9. doi: 10.1086/511985. Epub 2007 Feb 1.

Abstract

We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antitubercular Agents / pharmacology
  • China / epidemiology
  • Drug Resistance, Bacterial*
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycobacterium tuberculosis / classification
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / isolation & purification*
  • Patient Compliance
  • Sputum / microbiology
  • Tuberculosis / drug therapy*
  • Tuberculosis / epidemiology
  • Tuberculosis / transmission*

Substances

  • Antitubercular Agents