Optical coherence tomography analysis of bilateral end-stage choroidal neovascularization where one eye is treated with photodynamic therapy

Clin Exp Ophthalmol. 2007 Jan-Feb;35(1):13-7. doi: 10.1111/j.1442-9071.2006.01385.x.


Background: To compare retinal thickness and subretinal hyper-reflectivity using Stratus optical coherence tomography (OCT3) between the eyes of patients with bilateral end-stage exudative age-related macular degeneration (AMD), where one eye has been treated with photodynamic therapy (PDT).

Methods: Patients with PDT-treated stable choroidal neovascularization (CNV), defined as a fibrotic lesion not requiring treatment for 6 months, in one eye and an untreated end-stage CNV (disciform) scar in their fellow eye, underwent refraction protocol logMAR visual acuity (VA) in letters, slit-lamp biomicroscopy, fluorescein angiography and OCT3 scan. Subretinal scar thickness was measured as Outer High Reflectivity Band Thickness (OHRBT) and retinal thickness as neuroretinal foveal thickness (NFT) on OCT3.

Results: Thirty-two eyes of 16 patients were studied. Mean OHRBT was 255.62 microm in treated eyes and 350.8 microm in untreated eyes (P = 0.001). Mean NFT was 130.3 microm in the treated eye and 79.9 microm in the untreated eye (P = 0.017). Mean VA was 42 letters in treated eyes and 15 letters in untreated eyes (P < 0.005).

Conclusion: Based on OCT3 findings, eyes with AMD treated with PDT have a thinner fibrous scar and better preserved retinal thickness when compared with untreated fellow eyes with end-stage fibrotic scarring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Choroidal Neovascularization / diagnosis*
  • Choroidal Neovascularization / drug therapy*
  • Cross-Sectional Studies
  • Exudates and Transudates
  • Female
  • Fluorescein Angiography
  • Humans
  • Macular Degeneration / diagnosis
  • Macular Degeneration / drug therapy
  • Male
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use
  • Prospective Studies
  • Retina / pathology*
  • Tomography, Optical Coherence*
  • Visual Acuity


  • Photosensitizing Agents