Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon

FEBS Lett. 2007 Mar 6;581(5):975-80. doi: 10.1016/j.febslet.2007.01.083. Epub 2007 Feb 7.


Cytokines control cell differentiation, proliferation, and function by regulating gene expression program. Physiological roles and induction mechanisms of cytokine-inducible genes are not fully understood. Here, we identified a novel immediate-early cytokine-responsive gene, cyclon (cytokine-induced protein with coiled-coil domain), which is induced in a hematopoietic cell line by interleukin 3 (IL-3). cyclon gene encodes a phosphorylated nuclear protein consisting of repetitive sequences in the amino-terminus and a coiled-coil domain in the carboxyl-terminus. A novel transient reporter assay revealed that mouse cyclon promoter contains redundant elements for IL-3-induced gene expression.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • Cloning, Molecular
  • DNA Primers / genetics
  • Gene Expression / drug effects
  • Humans
  • Interleukin-3 / pharmacology*
  • Mice
  • Molecular Sequence Data
  • Molecular Weight
  • Oligonucleotide Array Sequence Analysis
  • Phosphorylation
  • Promoter Regions, Genetic*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Rats
  • Sequence Homology, Amino Acid
  • Suppressor of Cytokine Signaling Proteins / chemistry
  • Suppressor of Cytokine Signaling Proteins / genetics*
  • Suppressor of Cytokine Signaling Proteins / metabolism


  • DNA Primers
  • Interleukin-3
  • RNA, Messenger
  • Suppressor of Cytokine Signaling Proteins
  • cytokine inducible SH2-containing protein

Associated data

  • GENBANK/DQ501251
  • GENBANK/DQ501252
  • GENBANK/DQ501253