Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon

AIDS. 2007 Feb 19;21(4):527-8. doi: 10.1097/QAD.0b013e328045c4bd.

Abstract

Among rural populations in Cameroon, HIV-1 prevalence is low and the genetic diversity broad. An unusual population-level genetic background may modulate this pattern of HIV infection. We examined HIV-1 prevalence, CCR5Delta32 and CCR5 promoter -2459 G genotype frequency among 1390 rural inhabitants. No individual was identified with the CCR5Delta32 allele, but homozygotes for the CCR5 promoter variant -2459G (27.5%) were relatively common. A seroprevalence of 3.1% of HIV-1 was reported.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cameroon / epidemiology
  • Gene Frequency
  • Genetic Predisposition to Disease
  • HIV Infections / epidemiology
  • HIV Infections / genetics*
  • HIV Seroprevalence
  • HIV-1*
  • Humans
  • Receptors, CCR5 / genetics*
  • Rural Health / statistics & numerical data

Substances

  • Receptors, CCR5