Graft-vs.-host disease in lung and other solid organ transplant recipients

Clin Transplant. 2007 Jan-Feb;21(1):1-6. doi: 10.1111/j.1399-0012.2006.00573.x.


Graft-vs.-host disease (GVHD) is an uncommon complication of solid organ transplantation. Herein, we report a case of GVHD occurring in a lung transplant recipient and review 29 reported cases of GVHD that complicated thoracic organ, and non-hepatic intra-abdominal organ transplantation. The major presenting clinical symptom of GVHD was skin rash. Less frequent clinical manifestations were cytopenia (16%), diarrhea (11%), and fever (5%). The mainstay of treatment was high-dose corticosteroids. The mortality rate was high (30%). The cause of death was mainly due to infection, suggesting that antimicrobial prophylaxis may improve the outcome of this potentially fatal complication.

Publication types

  • Review

MeSH terms

  • Adult
  • Graft vs Host Disease / epidemiology*
  • Humans
  • Lung Transplantation / adverse effects*
  • Male
  • Organ Transplantation / adverse effects*
  • Prednisone / therapeutic use
  • Treatment Outcome


  • Prednisone