T-cell potential and development in vitro: the OP9-DL1 approach

Curr Opin Immunol. 2007 Apr;19(2):163-8. doi: 10.1016/j.coi.2007.02.011. Epub 2007 Feb 15.


In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors. Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent development of the OP9-DL1 cell culture system, a two-dimensional T-inductive environment, has provided greater access to the processes of commitment and development in T lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cells, Cultured
  • Humans
  • Lymphopoiesis*
  • T-Lymphocytes / immunology*
  • Thymus Gland / cytology*
  • Thymus Gland / immunology*