Control of peripheral B-cell development

Curr Opin Immunol. 2007 Apr;19(2):143-9. doi: 10.1016/j.coi.2007.02.010. Epub 2007 Feb 15.


Three subsets of mature B cells exist in mice: B-1, follicular and marginal zone B cells. The recruitment of newly formed transitional B cells into these compartments depends on signals emanating from the B-cell antigen receptor, possibly in response to (self-)antigen recognition. Recent evidence suggests that peripheral B-cell fate is controlled by B-cell antigen receptor signal strength, acting in concert with the cytokine B-cell activating factor. Other work indicates that peripheral B-cell development is orchestrated by a complex network of transcription factors, which drive B-cell subset differentiation, at the same time preventing mature B cells from undergoing trans-differentiation or premature terminal differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Cell Activation Factor Receptor / genetics
  • B-Cell Activation Factor Receptor / physiology*
  • B-Lymphocyte Subsets / immunology*
  • Gene Expression Regulation, Developmental*
  • Lymphopoiesis / genetics*
  • Mice
  • Receptors, Antigen, B-Cell / genetics
  • Receptors, Antigen, B-Cell / physiology*
  • Transcription Factors / metabolism
  • Transcription, Genetic


  • B-Cell Activation Factor Receptor
  • Receptors, Antigen, B-Cell
  • Transcription Factors