Role of ubiquitin- and Ubl-binding proteins in cell signaling

Curr Opin Cell Biol. 2007 Apr;19(2):199-205. doi: 10.1016/j.ceb.2007.02.002. Epub 2007 Feb 15.

Abstract

Besides tagging proteins for degradation, ubiquitin is now recognized as a signaling module for diverse cellular processes, including progression through the cell cycle, DNA repair, gene transcription, receptor trafficking and endocytosis. Recent advances have indicated the existence of a wide variety of ubiquitin-binding proteins that, upon recognition of conjugated ubiquitin moieties, can control assembly of complex signaling networks. Small ubiquitin-like proteins, like SUMO, emerge to play biological roles distinct from ubiquitin, and require specific recognition by a dedicated set of proteins. Identification and characterization of recognition motifs and domains for ubiquitin-like proteins have just begun, promising new insights into the diversity of functions ubiquitin family proteins have in physiological and pathological settings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / metabolism
  • DNA Repair
  • Endocytosis
  • Humans
  • Models, Biological
  • SUMO-1 Protein / metabolism*
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Transcription, Genetic
  • Ubiquitin / genetics
  • Ubiquitin / metabolism*
  • Ubiquitins / metabolism*

Substances

  • Carrier Proteins
  • SUMO-1 Protein
  • Ubiquitin
  • Ubiquitins