The JNK signal transduction pathway

Curr Opin Cell Biol. 2007 Apr;19(2):142-9. doi: 10.1016/ Epub 2007 Feb 15.


The c-Jun NH(2)-terminal kinases (JNKs) are an evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases. Recent studies have improved our understanding of the physiological function of the JNK pathway. Roles of novel molecules that participate in the JNK pathway have been defined and new insight into the role of JNK in survival signaling, cell death, cancer and diabetes has been achieved.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Death
  • Diabetes Mellitus / metabolism
  • Humans
  • JNK Mitogen-Activated Protein Kinases / metabolism*
  • MAP Kinase Signaling System*
  • Mitochondria / metabolism
  • Models, Biological
  • Neoplasms / metabolism


  • JNK Mitogen-Activated Protein Kinases