Endocrine effects of breast cancer treatment

Semin Oncol Nurs. 2007 Feb;23(1):55-70. doi: 10.1016/j.soncn.2006.11.006.


Objectives: To discuss long-term physical effects of treatment for breast cancer including effects on reproductive, bone, sexual health, and related women's issues.

Data sources: Research articles, abstracts, literature reviews.

Conclusion: Long-term effects of treatment have become increasingly prevalent in breast cancer survivors. The most common are effects on reproductive, bone, and sexual health.

Implications for nursing practice: Long-term effects of treatment can have a significant negative impact on the long-term health and QOL of women with breast cancer. Oncology nurses are well-positioned to anticipate and address the reproductive and endocrine consequences of breast cancer treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adult
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use*
  • Bone and Bones / drug effects
  • Bone and Bones / physiopathology
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / nursing
  • Breast Neoplasms / physiopathology
  • Endocrine System / drug effects*
  • Endocrine System / physiopathology
  • Female
  • Fertility
  • Hot Flashes / drug therapy
  • Humans
  • Menopause
  • Middle Aged
  • Osteoporosis / diagnostic imaging
  • Osteoporosis / drug therapy
  • Osteoporosis / therapy
  • Ovary / drug effects
  • Radiography
  • Vagina / physiopathology


  • Antineoplastic Agents