Evaluation and management of recurrent early pregnancy loss

Clin Obstet Gynecol. 2007 Mar;50(1):132-45. doi: 10.1097/GRF.0b013e31802f1c28.


Recurrent pregnancy loss affects up to 5% of couples trying to establish a family. Evaluation classically begins after 3 consecutive miscarriages of less than 10 weeks of gestation but may be warranted earlier if a prior miscarriage was found to be euploid, or if there is concomitant infertility and/or advancing maternal age. The evaluation begins with an extensive history and physical, followed by a diagnostic screening protocol. Management must be evidence-based; unproven treatments should be avoided. If no factor is identified, many couples will still eventually have a successful pregnancy outcome with supportive therapy alone.

Publication types

  • Review

MeSH terms

  • Abortion, Habitual* / etiology
  • Abortion, Habitual* / genetics
  • Abortion, Habitual* / therapy
  • Counseling / methods
  • Cytogenetic Analysis / methods
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Outcome / genetics
  • Pregnancy Trimester, First
  • Preimplantation Diagnosis / statistics & numerical data
  • Risk Assessment / classification
  • Risk Factors
  • Surrogate Mothers