A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy

J Neurol Sci. 2007 Apr 15;255(1-2):1-6. doi: 10.1016/j.jns.2007.01.004. Epub 2007 Feb 15.

Abstract

To explore subclinical central nervous system (CNS) involvement in chronic inflammatory demyelinating polyneuropathy (CIDP), we recorded somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) using transcranial magnetic stimulation, to measure central sensory conduction time (CSCT) and central motor conduction time (CMCT) and examined brain and spinal cord MRI in patients with probable CIDP based on the American Academy of Neurology AIDS Task Force criteria. Eighteen patients with probable CIDP (12 males and 6 females; mean age at examination+/-SD, 45.8+/-17.0 years; range, 17-72) were included in the study. Of the 13 patients who underwent SEPs, one had prolonged CSCT (8%) and of the 13 who underwent MEPs, four had abnormal CMCT (31%). Cranial MRI revealed five of 18 patients had abnormal scans, only one of which showed multiple ovoid periventricular lesions suggestive of demyelination while none showed any intramedullary lesion on spinal cord MRI. Thus, 6 of the 18 patients were considered to have subclinical demyelinative CNS involvement which had lower disability on Global Neurological Disability Score (GNDS) (p=0.0061), a male preponderance (0.0537) and a larger compound muscle action potential (CMAP) amplitude in the median nerve (p=0.005) than those without. The decrease of GNDS with immunologic therapies was nearly significant in the former (p=0.0556) but not in the latter. The results of the present study suggest that subclinical CNS involvement in CIDP is not uncommon in Japanese patients and that CIDP with subclinical CNS involvement is more demyelinative thus responsive to immunotherapies while those without have more axonal damage and less responsive to immunotherapies.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brain / drug effects
  • Brain / pathology
  • Brain / physiopathology
  • Central Nervous System / drug effects
  • Central Nervous System / immunology
  • Central Nervous System / physiopathology*
  • Demyelinating Autoimmune Diseases, CNS / diagnosis*
  • Demyelinating Autoimmune Diseases, CNS / drug therapy
  • Demyelinating Autoimmune Diseases, CNS / physiopathology*
  • Drug Resistance / immunology
  • Electrodiagnosis
  • Evoked Potentials, Motor / physiology
  • Evoked Potentials, Somatosensory / physiology
  • Humans
  • Immunotherapy / methods
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neural Conduction
  • Peripheral Nervous System / drug effects
  • Peripheral Nervous System / immunology
  • Peripheral Nervous System / physiopathology*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / drug therapy
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / physiopathology*
  • Spinal Cord / drug effects
  • Spinal Cord / pathology
  • Spinal Cord / physiopathology
  • Transcranial Magnetic Stimulation
  • Treatment Outcome
  • Wallerian Degeneration / drug therapy
  • Wallerian Degeneration / immunology
  • Wallerian Degeneration / physiopathology