Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort

Gynecol Oncol. 2007 May;105(2):365-72. doi: 10.1016/j.ygyno.2006.12.034. Epub 2007 Feb 15.

Abstract

Objectives: In patients with a granulosa cell tumor of the ovary, the value of serum inhibin A and B concentrations for the assessment of disease status was investigated.

Methods: In 30 consecutive patients with a stage I-III granulosa cell tumor, inhibin A and B concentrations were measured in pre- and post-treatment serum samples. Clinical data concerning diagnosis, treatment and follow-up of these patients were related to serum inhibin A and B concentrations. Serum samples from 41 premenopausal females with cervical dysplasia served as controls.

Results: In 30 patients, 13 (43%) recurrences were observed during a median follow-up of 10 years (range 1-31 years). Serum inhibin A and B concentrations were elevated in respectively 67% and 89% of the patients at diagnosis, and in 58% and 85% at recurrence. Inhibin A and B concentrations were normal in all controls. Sensitivity of inhibin A testing for the diagnosis of granulosa cell tumor was 67% with a specificity of 100%, compared to 89% and 100% respectively for inhibin B (ns). Elevations in serum inhibin B concentrations predated recurrences by a median of 11 months. None of the patients in remission showed increased concentrations of inhibin A and B.

Conclusion: Inhibin B seems to be the predominant form of inhibin secreted by granulosa cell tumors and appears to reflect disease status more accurately than inhibin A. Measurement of serum inhibin B concentrations may be preferred for the follow-up of granulosa cell tumors.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Chemotherapy, Adjuvant
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Granulosa Cell Tumor / blood*
  • Granulosa Cell Tumor / therapy
  • Humans
  • Inhibins / blood*
  • Intraoperative Period
  • Middle Aged
  • Ovarian Neoplasms / blood*
  • Ovarian Neoplasms / therapy
  • Radiotherapy, Adjuvant
  • Uterine Cervical Dysplasia / blood

Substances

  • inhibin A
  • inhibin B
  • Inhibins