TRPML and lysosomal function

Biochim Biophys Acta. 2007 Aug;1772(8):851-8. doi: 10.1016/j.bbadis.2007.01.004. Epub 2007 Jan 19.

Abstract

Mucolipin 1 (MLN1), also known as TRPML1, is a member of the mucolipin family. The mucolipins are the only lysosomal proteins within the TRP superfamily. Mutations in the gene coding for TRPML1 result in a lysosomal storage disorder (LSD). This review summarizes the current knowledge related to this protein and the rest of the mucolipin family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Lysosomes / genetics
  • Lysosomes / metabolism
  • Lysosomes / physiology*
  • Models, Biological
  • Protein Binding
  • Protein Transport
  • TRPM Cation Channels / genetics
  • TRPM Cation Channels / metabolism
  • TRPM Cation Channels / physiology*
  • Transient Receptor Potential Channels / genetics
  • Transient Receptor Potential Channels / metabolism
  • Transient Receptor Potential Channels / physiology*

Substances

  • MCOLN1 protein, human
  • MCOLN3 protein, human
  • Mcoln2 protein, human
  • TRPM Cation Channels
  • Transient Receptor Potential Channels