Receptor tyrosine kinases: mechanisms of activation and signaling

Curr Opin Cell Biol. 2007 Apr;19(2):117-23. doi: 10.1016/ Epub 2007 Feb 16.


Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Coenzymes / metabolism
  • Enzyme Activation
  • Humans
  • Ligands
  • Models, Biological
  • Protein Conformation
  • Receptor Cross-Talk
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction*


  • Coenzymes
  • Ligands
  • Receptor Protein-Tyrosine Kinases